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姓名:黄学锋
出生年月:1967年10月26日
职称:主任医师;博士在读
1.学习经历:
1983~1988年毕业于原浙江医科大学,获临床医学学士学位;
1990~1993年毕业于原浙江医科大学,获肿瘤学硕士学位;
2001~2002年美国德克萨斯大学MD Anderson癌症中心从事肿瘤基因治疗相关的博士后研究;
2.工作经历:
1988~1994 年浙江大学医学院附属第一医院住院医师;
1994~2000 年浙江大学医学院附属第一医院主治医师;
2000~2003 年浙江大学医学院附属第一医院副主任医师;
2003~2006 浙江大学医学院附属邵逸夫医院副主任医师;
2007年~今 浙江大学医学院附属邵逸夫医院主任医师;
3.研究方向及临床专业:
毕业后一直从事结直肠肿瘤的临床诊断、治疗及与之相关的基础研究,主要研究方向在大肠肿瘤的发生、转移的机制研究,肿瘤的基因治疗等。
4.发表论文:
1) Gu J, Zhang L, Huang X, Lin T, Yin M, Xu K, Ji L, Roth JA, Fang B. A novel single tetracycline-regulative adenoviral vector for tumor-specific Bax gene expression and cell killing in vitro and in vivo. Oncogene. 2002 Jul 18;21(31):4757-64.
2) Lin T, Gu J, Zhang L, Huang X, Stephens LC, Curley SA, Fang B. Targeted expression of green fluorescent protein/tumor necrosis factor-related apoptosis-inducing ligand fusion protein from human telomerase reverse transcriptase promoter elicits antitumor activity without toxic effects on primary human hepatocytes. Cancer Res. 2002 Jul 1;62(13):3620-5.
3) Zhang L, Gu J, Lin T, Huang X, Roth JA, Fang B. Mechanisms involved in development of resistance to adenovirus-mediated proapoptotic gene therapy in DLD1 human colon cancer cell line. Gene Ther. 2002 Sep;9(18):1262-70.
Huang X, Lin T, Gu J, Zhang L, Roth JA, Stephens LC, Yu Y, Liu J, Fang B. Combined TRAIL and Bax gene therapy prolonged survival in mice with ovarian cancer xenograft. Gene Ther. 2002 Oct;9(20):1379-86.
4) Lin T, Huang X, Gu J, Zhang L, Roth JA, Xiong M, Curley SA, Yu Y, Hunt KK, Fang B. Long-term tumor-free survival from treatment with the GFP-TRAIL fusion gene expressed from the hTERT promoter in breast cancer cells. Oncogene. 2002 Nov 14;21(52):8020-8.
5) Lin T, Gu J, Zhang L, Davis JJ, Huang X, Cabbini G, Ji L, Fang B. Enhancing adenovirus-mediated gene transfer in vitro and in vivo by addition of protamine and hydrocortisone. J Gene Med. 2003 Oct;5(10):868-75.
6) Huang X, Lin T, Gu J, Zhang L, Roth JA, Liu J, Fang B. Cell to cell contact required for bystander effect of the TNF-related apoptosis-inducing ligand (TRAIL) gene. Int J Oncol. 2003 Jun;22(6):1241-5.
7) Zhu H, Zhang L, Huang X, Davis JJ, Jacob DA, Teraishi F, Chiao P, Fang B. Overcoming acquired resistance to TRAIL by chemotherapeutic agents and calpain inhibitor I through distinct mechanisms. Mol Ther. 2004 May;9(5):666-73.
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